August 12th, 2014 Original Copy. HIV final Chapter

By

Sampson Iro Onwuka

 

The title of this essay and in fact one of the more important essays of our generation should be 'Kicking the Ass of AIDS' but we shall open up on this topic by citing that Human beings have always found themselves challenged by all plaques since the beginning of time, that the great advantage of our time is the new techniques and new machines are being used, and are to investigate on this virus and are sometime successful in discovering of the agents responsible for these new virus and infection.

 

One of the few ways we could broach the subject of HIV is on the context of several stimuli which are voluble to deficient argument leading to this final Chapter. The First would be a conjunction which are conjunction with some of the breakthroughs in the medicine and the Study of DNA, (2) the second persuasion on the virus can be vied through the performance of the blood groups and Hemoglobin. There are practically new forms of diagnostic in terms of the blood types and in terms of the medicine that it involved. (3) The latest group may introduce us to the work of the second broach on the subject and the role of genes and chromosomes, Matt Ridley torching SRY, and here we begin by trying our minds on Matt Ridley. For that a HIV active and capable of holding on to the end of the Host, in what it did not plan to do, could not a virus that are not familiar to human beings, or unfamiliar or distant from animals in our environment, that a case can in fact be made that majority of the so called diseases resulting from various viruses, can be cured or relived with basic materials which only fulfills what may be lacking in these parts of the body,…we begin with the last………….

 

(Number 3)

 

Many of ‘Nature and Nurture’2003, like the ‘Genome; autobiography of specie in 23 Chapters’ (99) also by Matt Ridley and probably his best year, which are far from his dubious ‘Red Queen; 93 and annoying ‘Origins of virtue’ 96, he will pardoned for history of Francis Crick but for me ‘Nature via Nurture’ is an indelible mark of academic expression and scholarly, why he failed to put the dots on HIV and its chief causes in ‘Genome’ in 1999 seem to throw the light on what peered the meaning of his theories. But at least from his books on this topic we become richer with the facts that Chimpanzees have roughly the same number of genes as humans, and much familiar with the range of interpretative history of the blood groups and the responses to the environment and forms of 'Immune Deficiency Syndrome.

  

“It is now quite easy to build a link from the Watson-Crick gene to the Darwinian gene in real cases. Here is one, a gene on the northern tip of the Y chromosome called SRY. It is a tiny gene, just 612 letters long in a single exon (paragraph) of text – as simple as genes get. As a Mendelian unit of heredity, it replicates this 612-letter text. As a Watson-Crick unit of metabolism, it is translated into a 204 amino-acid protein called the testis – determining factor. As a Jacob-Monod unit of development, it is switched on it parts of the brain and just one other tissue – the testis – for just a few hours, usually on the eleventh day after conception (in mice). As a De Vriesian interchangeable pager, it is found in much the same form in human beings as in mice and all mammals, where it performs a similar function – masculinizing the body. As a Garrodian unit of disease, it is associated with various forms of sexual abnormality, most notably people with normal female bodies but have a working version of this gene inserted into them by devious biologist. Broadly speaking, all an embryonic mammals needs to become a male is to have a single SRY gene, and to become a female it merely needs to lack a functioning version of the same gene.”

 

“For those readers who like to know how the engine of a car works, SRY probably masculinizes a body by one very simple action; it switches on another gene called SOX. That is all does. Genetically male human beings are occasionally born with one of the other two SOX9 genes not working, and most of them develop into women with a skeletal disorder called Campomelic dysplasia. SRY.” SRY orders SOX, which switches on other genes in the brain and testis, LLXG, WTi, SF, Dax, Gata4, DMRTI, AML, WAT4, and DHH, and hoary list of alphabet genetic soup and the relative IQ of an individual and individual species seem to conform in his theory to the number of neurons in the functional adult brain of any specie or an individual, where the repeat isoleucine ‘I’ and Q for glutamine which (begins the code for Amino Acid) show the humans with 74 motif structure, the mouse with 61, fruit flies 24, and the worms with only 2 repetitions.

 

 

 

The role of SRY a gene that switches on and off of genes, can be compared to HOX genes – particularly HOX 8 genes that are responsible for switching on other genes in each stage of development, depending entirely on the genetic paragraph, including the formative vertebrae and the hands which are separate from the legs, and other parts of the body essentially alight on the activity of the cells and the genomic composition, including the long thorax of Python and are therefore promoter genes, no less different from SRY in action saving that the female in conjugation of this gene is passed over, and in the place of creating a new gene that is male, it moves to create to activate or promote a gene which for the genes that will become females, the male sex hormones are triggered, in essence the hormones where either not sufficient for SRY to activate them, or that they have high estrogen level that could not easily bond with the ionic surface of the SRY. In every respect of sense, we must clarify that the basic structure    

 

 Sex gametes are determined by the father through the promoter genes, therefore when some biologist asserted that “humans are female by default – a sex – determining gene SRY on the Y Chromosomes overrides femaleness to produce a male.”, we are confused as to what the biologist meant, for it seems that we become female by chance, perhaps the biologist is eager to say that we are by nature female, that the SRY gene is what makes it possible for male specie to arise. Perhaps is not well understood in so far as the promoter genes are concerned, for it seems that the one of the major part of the human body that separates the male from the female is the brain and the reproductive organs that from all things concerned about these two creatures, there are elements of origin. Going from what the Matt Ridley accounts of the importance of SRY in the body and how it separates the sexes, we may consider appropriate that ‘humans are default female’ to mean that the condition necessary for reproductive male is that it emerges from the female. The school that are responsible for this theory seem obtain a lot of their premise on Darwin and his anthology, does not mean that this should be a defense of his school of evolution or that for science to be authentic it has dive the veil of religion. In reverse to what happens not in the immediate circumstances of the repressor genes in a very family waters of bacteria and bacteriophage (Viral DNA), that a connection between the male and female gametes are performed to the splitting and reduction in size, we affirm that duplicity of the bacteria and its reproductive ability, its perhaps mainly due to size of the proteins or size of the bacteria, for if protein is of any particular size and weight it might prove to deleterious. Here, all of the copies of a bacteria or what they call daughter cells of the bacteria, are said to resemble that of the mother, would point to seminal argument the role of SRY genes so praised by Ridley and others are a misdiagnosis.

 

It is from this theory of the sex gametes and the reproductive abilities of both sexes that any origins can be made possible, in reality, it is this origins of life and the origins in evolution that can be measured as the root of the new virus called HIV, for all too clearly as for I have asserted that a reason exist for the XX chromosomes in females – which are nothing but proteins – that they exist because of the constituency of both Amino Acids involved and from all accounts, these amino acids are responsible for the formation of the XX, whose mitochondrial DNA show elements of the fathers and mothers, but due to the sex gametes are mainly female and can therefore reproduce. The XX Chromosomal DNA are bi-product of body, no less different from the circle every month as the body prunes itself, that it is closely related to an active bi-product of the body. The seemingly unnatural theory that is not confined to a particular science, but it may be clearly stated that even the Sperm is not alone as life of the human in smallest cells, it is itself equally a bi-product of male reproductive system. The copious structure of the Y chromosome is the reason why we stand and walk, but the proteins which the Sperm feeds on – either Y chromosome or X chromosome – are food for it and nothing more. From all comparative accounts,

   

 

 

 

 

 

Mario R. Capechi, Oliver Smithies (U.S) and Sir Martin J. Evens, 2007 were honored with Nobel Prize for Medicine in ‘Embryonic Stem Cells’ towards specific gene modifications, experimental models using   knockout muse is proven important to help modify cells in the body. There are over 200 types of cells are altered in protean environment and ESC ‘embryonic stem cells’ – the matrix of the changes that take place after fertilization. It is during the fertilization that molecules carried over from a different parent is passed to the next generation. Above, it should be indicated clearly that the first reproductive process took place in the male testis and no elsewhere and in laid conception of these organizer theory, it means well if we can show that that viruses at a very small unit compose as functional life the highest of the creature in terms of activity of neurons. Understanding the digestive processes

 

 Based on the original accounts of Michael Gottlieb on what he discovered was by him new set of biological conditions (it wasn’t) that all five of his male patients had a strange infection. We use this set theory of five male patient at the same time, al suffering the same sickness as a basis point for a new set of virus. Each of these patient had ‘pneumocystis carinii’ (now Pneumocystis jirovecii), which was usually a harmless cold virus which the human immune system should have handled very easily. (2) The profligate virus quickly filled their lungs and these men drew with evidence of all candidiasis. (3) Their Fungus lymphocytes were very present and showed a depleted Thymus depended cells (T-cells). At the same time, Alvin E. Friedman-Kien and company found 26 cases of Kaposi’s sarcoma among New York ‘homosexual men’ and they all had pneumocystis pneumonia. For all the important attribute, it was the company of the five male patients with depressed immune system that proved a broke back for these cases in the way it was conceived. For that reason, it begins to make sense that this was a new virus, and may have entered public consciousness for this reason, that in fact Michael Gottlieb and company were speaking of a new virus altogether. There are no limits to speculations about the virus, especially seems it contained some cold elements about, and seem to have a phenotype similar to some strain of monkeys and chimpanzees left in several labs in New York.

 

The same is the case with 'Random DNA mutation' as implied by Ernst Mayer and to some degree Charles Darwin, as nearly adopted by Gould, Vrba, [exaptation] is known to be primarily destructive - even for the second phases of Mendelian Pea concept of Inheritance. To be clear, it is not wrong to suppose that the argument is true that all spontaneous changes in generic materials of humans are hardly positive.  But this is what Darwin had in mind in terms of 'mutation of species', which took his mind and the interpretation of his book to a whole different and irregular ends. Such ends left Darwin a messenger of the transfer of specie by means of evolution from one base form to another. Given the immense influence of the Theories of Evolution, it will be hardly missing a point that the shift from one specie to another as with primates and humans, was suggesting that human beings and eventually Homo-sapience emerged from less desirable primate to what is conceived as human beings in the light of modern theory. The influence is not unlikely to demised, no doubt rewarding, for how could science challenge some of the basic assumptions in religion without toing an alternative line of thinking which Theory of Evolution by Natural Selection offer?  But this theory is why there was such obstacles towards a final resolution of virus, for if evolution theory is correct in the form Darwin explicated, it would have been possible to show that HIV could have transferred from one primate to Human, and like the background to all theories of SIV and Feline SAID in the redeeming labs in New York and California, this shift is essentially false. That one of the central dogmas of theory is the transfer of SIV into Human HIV, whereas some diseases can transfer from animals to humans, the primacy of cancer and cancer causing agents in monkeys, do not really profligate in human beings, the human body will likely digest any SIV including the meat of monkeys without being sick. Fact is, SIV in truer light of actual is probably a cancer oncogenic virus in monkeys, does not mean it is a parallel to HIV and therefore subtends on the argument that SIV is a retrovirus cancer agent for Siamese primates and differ from HIV as with the same reasons as Gallo’s HTLV. HIV is slow (visna-like) virus, not a visna or bovine virus since these two virus create demythilation of the cells as such similar to oncogenic HTLV and SIV saving that these last two induce symptoms mainly familiar with HIV; blood sickness of some explicable variety.

 

 From the piece above, we gradually yield to the problems of scientific interpretations regarding the viruses from Africa and the once from humans. For if we suggest that this interpretation of the data more than defined the age of scientific inquiry into HIV, we may perhaps grasping the straw on the failures of artificially created devices and the body naturally employed by the human body. For example, a corroboration between a Scientist and a Journalist in Tinderbox (2012) by Craig Timberg (Journalist) and Daniel Halpern scientist at the University of North Carolina Chapel Hill relive this theory through their studies of the data from Cameroun. According to these authors the AIDs epidemic began in a “…small patch of remote southeastern Cameroon…” that it started “…within a couple decades on either side of 1900.” That “…somebody caught an infected Chimpanzee for food allowing the virus to pass from the Chimp’s blood into the hunter’s body, probably through a cut during the butchering…”, and by this they intend to suggest that it was the intrusion into remote parts of Africa that brought the virus from its primitive hide-out to modern society. To make the case more compelling, the authors indicated it was in Africa “…that a strain of virus called HIV-I group M first appeared. In the century since it has been responsible for 99 percent of all the world’s death from AIDS – not just in Africa but in Moscow, Bangkok, Rio De Janeiro, San Francisco, New York.…” Daniel Halpern also added that the spread was possible through circumcision and high sexual behavior among the said group of Africans.  Going from the above examples and the direct similarity and differences between the cancer causing viruses much of which has not been correlated to humans and the slow killing devices of HIV, we may certainly indicate that this cannot be scientific true.   

 

The second example is with David Quammen ‘Spillover’, when he gave us a scenario; “Let’s suppose that fifteen, different consumers partook of the chimp meat and that they all remained fine. HIV negative lucky folks. Let’s suppose that only the cut hunter became infected directly from chimps.” –that at the beginning of the Virus R0 and 1.0, nothing really happened, then “The virus seems to have traveled just as people traveled in those days mainly by River. It made its way out of Southern eastern Cameroun along the headwaters of the Sangha, the down the Sangha to the Congo then down the Congo to Brazzaville and Leopoldville, the two colonial town on either side of what then was skill known as the Stanley Pool. “Once it got into an urban population,” Hahn said “It had an opportunity to spread.” We can generally and summarily call this assertion untrue, and perhaps unscientific, for the drastic bases on which this theory is based is wholly misleading, or at least poorly correlated to biology and man. Every so often, we find accomplished experts fumble in the long studies of sciences, in biology, physics, Field Theory etc, but there are cases that reveal something else.

 

 We read from Quammen about the results of another scientist by name Vanessa M. Hirsch who in his words, revealed that “SIVsm has infected macaques in capacity and humans in West Africa, and evolved as SIVmac and HIV-2, respectively” and it was possible to show “that the SIV (cpzptl) strain that gave to HIV-1 group M belong to a viral lineage that persist today in p.t troglodytes apes in South eastern Cameroun.” According, “That virus was probably transmitted locally. From there it appears to have made its way via Sangha River (or other tributaries) south to the Congo River and on to Kinshasa where the group M pandemic was probably spawn.” Let’s get it clear, from the two citations that a hunter was perhaps bitten by a Chimp or by some exposure to Chimp meat, he got infected and somehow he became the carrier of the virus – which may have trans-mutated into HIV – made south of Cameroun river and down wards to Congo and ultimately it reached Brazzaville where it spawned like crazy.  It is a difficult intellectual sketch this is hard to challenge, but couldn’t have true, for many reasons other the impossibility of catching HIV from a Chimp’s meat. This ideas has been tried and more than once, and people ate chimps meat with SIV which is clearly oncogenic, yet these Africans and whoever fed them these meet without their knowledge did not become sick or HIV positive. These meats, inside the dangerous cases of infected microphages are abhorrent as far Africans are concerned – though have testified to eating Chimp’s meet - and when eating, would easily be digested by the body as normal food. In simply terms, you stand a better chance of been affected with unusual viruses when you consume a human meat or carcass than say a Chimp or a monkey. In all truth, there is no a chance in the world that any HIV could arise from Chimp’s immune defenses and SIV and Quammen’s  adaptation of Brandon Keele Papers about the River, including Mario Santiago, Martine Peeters, and the great Beatrice H. Hahn is not saved by science and biology.         

 

 

It becomes interesting when we put Robert Gallo’s team into the equation. It is easy for us to relapse into vaccine studies at the height of Polio, and how they monkeys and chimpanzees removed from Africa – about 100 thousand over a century or so, could threshold the familiarity between the two primates to the point of using the viruses from monkeys and chimpanzees in Zaire as model for humans. Gallo proved that these were possible, but it may be clear that once indicated that the deep Cameroun boundaries and the Congo basin and areas where the origins of HIV could be cited. It goes us the impression that he equally suspects remote areas of Cameroun and Africa as the origins of HIV. All globes apart, it looks like that influence of the Polio vaccine using primates when in full revealing knowledge of the Polio dynamics, these primates were not that necessary, that a school of comparative anatomy will point to human and primates are organized community that could in many respect share more than one thing in common. They look alike, and if the Africans can suffer means that Europeans can suffer it, also means that in a chain of unraveling, there is an ode we follow. This is strictly Darwinian and his influences are so profound that only those outside the box can find glaring holes in the arguments. The origin of the virus HIV or where is mainly located is no less a problem and shouldn’t have been with Gallo and his clearing on such topic.

 

 

The corrections on this assumption are long and observed that it almost amount to some kind of defense, yet Polio virus from plain origins could have started anywhere, is known to have reached Africa but it is probably not true that it was original to African. In other parts of world, the presence of what seem to be similar to HIV in form of PCP is common place, but this fact crumbled in the face of the foundations whose pillars converged to Africa, or any region in the world, and it seems to have gathered dust among scientist. It is tradition that several diseases not familiar with man is perhaps deeply in severe locations of the world, as such the moving from these creatures to human could have resulted from recent contacts and may have triggered dormant bacteria or viruses which cause 75% (three quarters) of the Cold virus in human beings to emerge. All the same, much of these viruses which simply lay dormant only remain dormant until a compromised immunity essentially takes over the body. The discoveries of the French team lead by Montagnier are no more than what they are, exception based on the virus that used as a prototype, to the point that a connection to the earlier years of those whose Kaposi Sacoma in New York could not be treated and who deficient in the defense network, points to deviant sexual behaviors, to some point separated from those in Los Angeles, who though had the same virus evident in their body, where also showing some depression in the system and the presence of candidiasis including breathing problems. It is therefore not an immaculate conception that the breakdown in the body of those diagnosed with Pneumocystis – itself a fungus with some of its element as copiously bacteria without walls  usually classified as Mycobacteria loosely for they do in epigenetic methyl based complexes, than the cold they could create,-  perform the same havoc when tripped like staphylococcus and streptococcus which perform separate disorder in the body but primarily infection leads to cold, either in the first primary phase or when contracted through a secondary agent. 

 

 Here it will be rewarding to show that mycobacteria is not a new name in the market, it is has been and for many scientist for instance Lynn Marguilis and her colleague Dorian Sagan, have given some academic devotion to the transformation that take place in the life of a bacteria and how these mutational changes, from one area of the chromosomal to another adds meaning to what is now called Epigenesist which..., and which Adesinine and Guanine based protein building on a three level phosphorylation within the cell and through diacyglecrol perform separate respiratory function relative to the ions of the surface, where a short and misconceived attraction and relapse duration(cell respiratory on the Golgi body) can affect the false release of information and trigger event reaction from the cell are based on some role of oxygen. If we recall briefly the experiments of Oswald Avery on pneumococcus, there is an express that he defined about Deoxyribonase Nucleic Acid (deoxyribonucleic acid) there he emphasized thymine as operand towards the creation of new DNA.

 

some multi-celled organism living in the gut of say Cow or in its intestines, which are naturally used for the reproductive processes of a milk (bi-product) are not normally known to be destructive, may remain friendly in the gut and intestines of the Cow or other mammals until the frequency of the cells or immunogenic is comprised….It is these two viruses that are equally significant in the defenses and failures for and against HLTV virus which are generally oncogenic such as the ras and abl and to some arguable degree yes genes in blood and pneumonia related cases can be represented as viruses received from several range from bare-back viruses such as mycobacterium, particularly Avian which is a Sars virus which is respiratory based virus and in like viruses or multi-cellular organism and their viruses….    

 

 Lynn Marguilis and Dorion Sagan (The Theory of the Origin of Species, 2002) clarified that "Mutation accumulation does not lead to a new species or even to new tissues. If the egg and a batch of sperm of a mammal is subjected to mutation, yes, hereditary changes occur, but as was pointed out very early by Hermann J. Muller (1890 - 1967), the Nobel Prize winner who showed X-rays to be mutagenic in fruitflies, 99.9 percent of the mutations are deleterious". Lynn Marguilis indicated that species are a product of symbiosis, and in terms of Ernst Mayer's word 'symbiogenesis' which must be conflict with Darwin's principle of gradual evolution, where She and Dorian Sagan widened all concept of speciation to include all human beings. They further indicated that "our symbiogenetic definition of species is as follows.” And further suggested “that if organism A belongs to the same set of integrated genomes, both qualitatively and quantitatively, the All organism that can be assigned to a unique species are products of symbiogenesis" which to a large extent mirror s the demands for explicating the problems of the two headed virus such as the Retro Virus.  The above idea is smart and simple since 'a cell by nature explains its evolutionary history' a postulate, more meaning for a 'specie' as individual than all else, a cheap but dangerous idea since a given mass of proven material against Darwin 'mutation of species' exist, and it is irrespective of De Vries 'metamorphosis' since the examples of butterflies formation affected by externalities such as drought leading to 'incomplete metamorphosis' is necessarily temporary and durable only to a specie and a phenotype.

Man, Darwin argued, began his very existence thus described, enabled its existence by the will to live, resulting its final form as a creature first crawling, then squatting and then to full human beings. Darwin attempted to buttress his argument (but to blunder) by citing changes over a long and inaccessible period of time and through 'mutations of species', a condition which is proven then and now as abiotic and deleterious.  The imperial weight of the changing dynamics of the human cold viruses and bacteria is why there is new need for vaccination against influenza every year. The cold with its new pollen dust simply trips the dormant and friendly viruses in the body leading to dysfunction of the type I and II alpha globulin defense system in names of mucous and in the names of microfibers in the intestines where lymphocytes depressed histones mount a first attack – albeit sneezing or allergic reaction.   

 

 Change in time through mutation of species as De Vries attempted to show bends to this Darwinian idea of 'mutation' - if not Lamarck. But as far as the point that 'mutation of species' which is the central fix in De vries argument - he, De Vries, is become a product of the past or a casualty of his time. De Vries is particularly known for mutation of species, which made him uncommon, without, which is part of the long list of flawed introspection. He would have done better with his concept that changes are relative to the individuals, and stayed away from 'mutation of species' (transformational evolution). Weirdly enough De Vries, alongside Bateson, Johansen are called Mendelians, and their influence in Biology is quite deep particularly the reasons why Mutations occur and how oncogenic cells is said to be Inheritable when this is probable not exactly the case. It is true that can some diseases are reasonable associated with a variety of people in the world, and are associated with various groups of regions and specie types, but these diseases and how biologically susceptible we are to some diseases are not particularly limited to our kind, or a specie, to the degree that DNA has successfully replaced the idea of mutational changes, it is only common sense that proteins and its quality which are the main reasons for biological changes in the body and why we differ from each, explains the reasons why viruses and bacteria familiar isolated for specific diseases were successfully based on the outer-coating of the viruses and bacteria, and the coat enables specific roles of the restriction enzymes towards the splicing and replacing of DNA, and the implication when each of the Phosphate strand is the complex. The region that the restriction occurs in both bacteria and viruses, and the permeation of some of the bacteria and their viruses, is a fascination that is explicable through the Random DNA Mutation but which should merit additional studies largely for the precision information available today, and also for the inherited bias associated with Darwin’s theories, that for instance evolution of human beings may be specific to certain regions of the world, and alternately over time as people travelled around the world, they became specific to these environment.

 

The short expression of this theories and why without our consideration it hinders on final solutions on HIV, is that somewhere, some nature protein types and including biological life-span are ridden to an environment and may have transferred from one form to another, creating species of several kinds including the human races and in very recent estimate the use of Drosophila (house flies) to show the degree of inheritability and not necessarily mutation, a work which begin in limelight Koch, addressed to some degree by Hunt basing his argument on Weismann, and then finally mastered by Debonsky, who largely developed the examples on Drosophila and the phenotypes, and why many of the mutations that occur in these flies are usually within a life-cycle, are non- transferable, and are sometimes cancerous. Point to be taken here is that the changes that take place in a life time are due to many things, but some of these changes are gradually for instance Red eyed flies or White flies may generally loose these features over time, due mainly to biological but gradually isolated changes as opposed to a one-time horizon also called Epigenetic, that is perpetuated by recurrence in of base pair in the formative hydrogen determine combination between the purine and pyrimidine. It would be clear that smashing this theory or this house built on Darwin as a way to come to terms to the formal oocytes’ evolution, which no doubt contains information from both parents, no doubt explains why we are similar and different, no doubt demonstrate the reason why we have White and Red Cocks and hen, no doubt explains why there is a White skinned human with physiology that are also different from those of more moderate Oriental with their biological differences and then the primal race of the Africa spared in many regions of the world. These changes that attributed to oncogenic effects of Melanin proteins, which refuse to turn on during meiotic and are assumed as perpetuated to deletion a base pair and hence a recurrence, is entirely opposed to what we would have obtained when all the histories of world and man combine, that a one-time event of for instance Albinos is no guarantee that it will repeat to the next generation, is not itself a process of incorporation of new genes to the body, rather a process within a process, a deletion of a first level whose repair is probable through second and third primacy cases of meiotic – during the length and expansionary region of isolation – or in terms of say a white of slightly weaker genetic protein and the older and genetic richer blacks – the gaps no less biological and equal to a period in time – does not transfer to the other gaps in the evolution tree (if at all it occurred as explicated by Darwin’s theories) and the time frame of physiological descent through reproduction isolation to perpetually take place. The gradually motive is to confined to anywhere in the histories of the world, confined to any region in the world, does not mean that black for instance as a race are older than others vice versa, that there is continuity which human body ensures and effective studies on how these continuity occurs and why Bacteria levels and  

 

 It seems that a visit to the period of synthesis achieved in my view through the Theodosius Debonsky, concerning the limits of Darwin’s evolution theory and the limits of Mendelian biology. Jack Monod consign these group to the ancient past, build his view of experimental biology on his colleague Crick, and would have guessed that the only study necessary for advancement in sciences was at its genetic level. Perhaps we may have looked at the outline of Cricks and Watsons’ defining studies on Double Helix, especially a book with similar title by Watson ‘Double Helix’, and we are so many years ahead of others who fielded their problems of understanding genetic information at a very small levels along Darwin and Mendel, who when confronted with Trofin Lysenko and his experiments with Winter Wheat and inherited or transferable characteristics, it becomes difficult in the light of proven biological experiment to dissuade the poorly understood concept of Lysenko. But if hybridization is in effect a theory that begins to allow Lysenko a place in biology, it is from here that his view approaching the second part of incomplete metamorphosis that his light dims in Mendelian approach. Above all, the problems of infection for instance witnessed in Cow Pox and in Small Pox, which the body extensively mounted responses and defenses, does not transfer to the periods of incubation primary in the case of HIV to the years or months necessary to weaken one’s immune system. There is a storage capacity that is done with purpose of the existing structure, rather it is process that builds on a process, more like the formation of synaptic muscles itself layers of the tendons but it said to govern or influence human reflexes without duel responses from the brain. Apparently, the primary biology of Golgi in his estimates of the separation between the ankles and the muscles did imply that the body is redundant on the information and responses to stimuli, one ability as we know release it to response to stimulus may give a sense of his conscious level and perhaps the dynamics of his or her brain. When Polio attacks the nervous cells, it may suffocate its process by attaching its own genetic material, which as we find in relation to monkeys and Chimpanzees look almost like humans, but in reality there are different. In paralysis the human nervous system estimated to be anywhere close to humans up to 98 percentile and going by the vindications of the genetic studies and the arrangements of the minerals on the Double helix and its Sugar Strand, it makes sense that not only the Chimpanzee and Monkeys the only creatures that could have afforded us a trade fair from their kidneys, testis, or spinal cords, each a repository of the blood developing…which is not different from HIV and its formal invasion of Spleen and Spinal Cords, could in fact approach a success rate similar to primates from other less attractive members of mammalian animal complex for instance the rat. The Question was finding which the mammals could support human immune response in such a way that MV virus trapped in Nervous cells would be expected at least in other primates’ case to relapse i98 percent of the time into areas which the Thymus could not otherwise manage. That the questions regarding the toxicity of …..   Had the emphasis on Mycoplasma….Let be said that if the final damages of Polio Myelitis in living the victims paralyzed is not a process that is transferable,  would also mean that persons of pure essence when exposed to this virus may suffer paralysis from waist down. It will be enough to have clarify the inability of a parent to transfer his or her condition to his or her children would lead to the preventive remedies in Lysenko regarding for instance Winter Wheat which usually die away through cases of hash winter but may be preserved through application of natural remedies for a Spring, would not mean that the genetic fiber is altered, would equally suggest that the preservation of the genetic materials by Lysenko was no less a treatment for a weather.

 

 

In Ridley’s view we can argue that, self-generated ‘immune-disorders’ which may look like a genetic disorder passed to descendants but are really a breakdown of a system’ other than disease, can be passed from one generation to another. In his view it will seem that the ‘immune disorders’ insubordinate to blood protein, as if the virus is reduced to one kind of RNA which is transferred from one blood line to another. We shall continue by indicating that from a host of information which is now available to us and from Ridley books, that the case of “sailic acid” and human ability, response and immune reaction to these acids show a degree of intolerance, that when our body ‘simply cannot tolerate this “GC” version of siallic acid, because we do not have it in the human body’ and Great Apes have it, because our body in his words do not have the enzyme to convert GC siallic acid to AC sialic acid, and is due to the 92 letter sequence,  may have arisen as a consequence to a sugar molecule found in humans but not in the Great Apes. Why this point is very clear and in fact obvious, it is common sense to suggest that this sugar missing from Apes, is expected to either target the process of conversion of GC to AC, that going at the rate of the transition from one form to another, a process that is left to ability of human beings to response to anti-bodies, either in error or in perceived notions of the role of thymus depended cells (T-Cells) and promoted sugar, and between a human reaction to say a cold virus and those of a Great Ape which react differently to it, we can be sure that biological complexes are products of their own existence.

  

Place Darwin in this scenario that humans would be said to have arrived at this stage from Great Apes and some Uncle Primates should encourage a conclusion that is common to biologist in our time, that a dip in phosphate sugar (demythlation – which is the only that can happen, and would render humans mutants of the Great Apes and limited to one life-time) or acquisition of one Sugar molecule from Great Apes (which does not happen) - with or without respect to thymine – arrived our human beings.

 

 If we tolerate this theory within the showing of Matt Ridley, we may confuse immune defense system with the functioning of thymine, or compose the GC and AC differences in Amino Acid composition among the Great Apes including humans as reasons why we differ. But the trend runs a little longer, for us to be sure that we are a product of our defenses, we may suggest that the extraction of one bacteria form to placate the effect of another is acceptable and tolerable biological limits that like molecules do not attract, that a difference exist between opposites and parallels, and this is the mindset of immune system – a parallel existence of baby virus immersed in the human enigma. To that general event we occlude that HIV like other reverse transcriptase can withstand all torture and slicing processes from human defense T-cells largely on its ability to mount immune response to human body in-of-itself. By the edge of the discipline in which immunology is composed, we may infer that a defense involves a conditioning of microbiological that has elements that a cell at local level can inhibit a profligate of an already acquired virus and bacteria form, as essentially arrest by the Chromosome 8, that in wisdom to the life of a cell from an egg form to a fully functioning human and further down to the smallest oxygen bearing Eukaryotic, that a system of self-defense is tolerable within the margins of protein transfer, to enabled degree of sharing chromosome at disappearing meiosis, to vaccination for human and animals or the invertebrates, that in all when any organism acquires the basic DNA of a second micro-organism, it can mount immune response to this organism.

 

 

We should take into accounting that human beings are not immune to these devises which they implore, that the bacteria – especially a viral form on the Phase II of its life reduced to virus and called HIV in this case, is or can be argued to have acquired immunity against its host, that is safe and secure within the host – that the host cannot really harm it as long it is on some of baby level from which it reproduces. But once the virus is in the cell, the circumstances change, the reverse transcriptase is reduced from its burden and then the copulation inside a Cytoplasm which DNA do not penetrate becomes reason to dictate the virus as a misnomer. 

 

We can throw more light on why the reductionist view on SRY was not exactly sciences in cog of promoter genes and why understanding the verifiable relapsing of this theorem in the context of Darwin is blind-spot for many attempts at HIV. Let it be clear that the choice of the Sex gametes are not incident to discovery of new viruses, that plants lack some action in the nucleus due to the fact that some flowers – if not most are considered Hermaphrodite – male and female -, that some mammals are known to even have XY for females and XX for males. In reality, there are degrees of separation between the male and the female stating that either male or female are usually different from each other. This is probable not different with humans, they have XY for male but unlike other creatures humans are probably by default male and female by actions of SRY – when it fails to turn on some reproductive organ, ends Darwin’s supposition of event horizon from aquatic to semi-aquatic to fully functioning humans. It also buries other probability that Ape were human ancestors, that some viruses could a-biotically transduce from Apes or Chimpanzees to humans, even to the land of Cancer causing agents which is the canopy of Gallo early viruses, oncogenic viruses that are cancer causing but has no corollary among humans.

 

 A new trial of this discussion can also be taken from Matt Ridley’s (2003) that, “The Virus that causes AIDS is a retrovirus, which means that when you catch AIDS, the genes if the virus are literally incorporated into the DNA in the Chromosomes of some of your cells. Because this happens in the blood cells and not in sperm or egg cells, such genes cannot be passed on to your offspring. But sometime in the distant past – and more than once – a similar retrovirus has managed to infect germ cells.” This a conundrum, a conundrum so central to the formation of HIV in which it became apparent that we must forcefully respond to Ridley, that this is not case at all, that though HIV is found in the blood of its victim, its journey did not begin at the blood stream as assumed by many authors, even in 2001 after looking after looking a few patient and their history, it was clear that the journey ended up in the blood stream where it is expected to course any major sicknesses. It gradually became clear that, at to best of me that the virus started at a different organizational sub-unit in the human body, that the retro-viral potency of the virus couldn’t have started with the first victim of what is probably a cold virus, it is was something else. 

 

It is the production of certain glucose and sugar splitting enzymes or protein promoter such b-galactosidase made it clear that thymine may be the victim here on account of what introduced the two pieces of streptococcus into the body. Assuming the bacteria is linked to similar bacteria like E. Coli such Staphylococcus which was also found in large quantity in the rectum of the victims of the HIV at the early beginning, and by that it seemed to many experts that either Streptococcus or Staphylococcus was the leading suspect saving that medicinal treatment – immunogenic drugs – did not help the victims. This gradually forced the attention of medical experts on Fungi, due perhaps to Candidiasis’ brutal explosion through the body, appearing in the mount and in various parts of the body. But these are dormant and sometimes harmless micro-organism, but seem to have taken a new note from a depression of growth inhibiting factor. The question that many doctors had problem answering is if the Streptococcus and Staphylococcus found in the male rectum is indicative of the primary agent, what about the women who engages in sorts sexual athleticism and bare-back with many of them having the same abnormal level of bacteria in the rectum. 

 

 There was a reason for this anomaly and most biologist would have failed to deliver on the answer – at least since 2001 when I marked down this reason, there are no books that has correctly indicated that the male digestive tract at a cell level is probably charged differently.  It seemed to me that we only inherit genes from our fathers and not necessarily from our mothers. How to provide this prove was a challenge. When I described to a friend that either reproduction is digestive process or vice versa, that the Chromosomes that we are said to have shared during mitosis seem to be based on the cells ability exhibit parallel existence or gene pairing, that it was like terms, they would never part ways – may remain fused forever. But the genes realign because they are parallel, they are ridden from fathers or male, that is genes from the male couldn’t bond with genes from the female because she retained genetic factors of her dad which her genes and those of her mother’s conditions and probably does nothing else, and these genes are by parallel existence transferred to the next generation.

 

 Among the early triumphs of the virus are those by Michael Gottlieb who used the ‘monoclonal antibody analyses’ to indicate which T-lymphocytes was affected and which bears antigen or marker OKT4 or what is now known as CD4 and these White blood cells are very important for ‘cell mediated immune defenses’ and the author ideated in Gottlieb showing “that T-lymphocytes with suppressor function, which carry the OKT8 surface marker (a marker which also identifies the so-called killer T-lymphocytes) were relatively reversed. In all patients studied, the helper-to-suppressor T-cell ration was reversed.” Gottlieb discovered in the sperm of HIV patient strains of the virus and above all it seems more than likely that it was begun by the male and not the female. A better discussion can be mounted on this topic, but loosely channeled to dominating theme of the formative virions, its understanding and the triumph over it does not lie in the blood.

 

“We know the many different copies of complete retroviral has managed to infect germ cells.  We know this because the human genome contains many different copies of complete retroviral genomes, recipes for making infectious viral particles.” Why? It seems that retroviruses are found in every creature that acquired a foreign DNA in the course of its evolution. This is especially true for humans who from birth are prone to new viruses and bacteria, where the role of SRY plays a significant role – so associated with Chromosome 5 – responsible to our ability to accommodate our environment even at the Chromosomal level during its mitosis as progenically male is turned and the rest left without promotion ends up female. It is far from XX, XY argument and what we believe we inherit from our mothers and fathers. It is a digestive process, meaning that reproduction is form of digestive process, or digestive process is a different kind of reproduction. It is  

 

No need to explain that the whole thing did not go well after that.  I assume that Darwin is not to be blamed for the obvious lack of induction on its merit, rather institutional errors can be passed from generation to another – for only when the right measure of wrongs are righted can the revealing final come.

Ridley continues that “They are called hervs (for human endogenous retroviruses), and they sit among our own genes as parasitic intruders. We pass them on to our offspring. Indeed, simplified and abridged versions of these viral genomes are among the commonest motifs in our genome – they are the so-called jumping genes that make up nearly a quarter of our DNA. We human beings, at the DNA level, substantially descended from viruses.” Why? Why is HIV any different from other viruses and retroviruses in the human body, and why is it able to withstand human immune system? It is able to withstand all that the body was manufactured to deal with because it acts like a new virus with seemingly new proviso for human genetic template and immunity.

 

 But it is true and most accurate that we can only inherit genes from our fathers – personal dogma, that we are by default male – personal dogma, that reproduction was either a process of digestion or digestion a process of process of reproduction – especially at a lower level. That we inherit what cannot be paired and not as we may have learnt over the years concerning the pairing of two parents and division during mitosis – a personal dogma, that life may have started on the smallest possible unit is correct, we couldn’t have evolved as Darwin described it – that in fact Darwin’s theory is persuasive but ultimately wrong – personal dogma. The theory regarding the crossing of human beings to different parts of world from a time when it was together is not exactly correct – to a point that species are not fated to one region – a personal dogma. That in so far as HIV is concerned, its evolution began in the male testis and nowhere else – a personal dogma, it was it was enucleated in the testis with perhaps the help of thymine or similar such which the bacteria producing galactocidase introduced, that the potency of the virus could not have started with a first male since virus are not without surprises sometimes found in the sperm of the most sick men, but the life cycle and the bi-layer was completed in the testis of the Second male not female - a personal dogma. Induction is a process which a bacteria sometimes acquires a new life-form from previously existing life-forms.

 

All that the bacteria has to do was loose its protein structure, and adapt to the new body or the body of the host without losing its chromosome. You should not be looking for a bacteria form especially in Phase II Viral RNA form to be suited in the same protein outfit, for if that is always possible, bacteria that sometimes support life would not necessary. But in digestive process, that a human immunological complex in compromised and growth inhibiting factors tripped – either through illicit drug consumption (supported Deusberg) – for instance during an introduction of Cortison to create cold (Verghese) which could replace Cytosine in the blood building chain  or through natural consequence of leukemia induced conditions such as Hemophilia, etc – that such repression leads to a repression of immune system and Streptococcus or Staphylococcus taking over the body, these bacteria much like E. Coli which can induce thymine dissolving sugar complexes could trip the blood building complex, creating mutant cells and a depression of the Red blood cells and then a continues repression of White blood Cells (T-cells), a victim might give in to some sickness, usually a cold related sickness or cold related condition and may be seen with to be sick for a while. Usually most people recover but in some severe circumstances, the body may be too weak to resist a profligate cold virus or any Viral age RNA harassing the body, it passes the antigens of the virus or bacteria as waste from the body. In this context, we relight the fact that even the Spermatozoa is a bi-product of the human system. The only difference is that unlike much of the excretes from the body in semi-dissolved life forms, like the female eggs and her mensuration, the male sperm is the only fully active summary of life – either from a male or adopted from somewhere else. It has a propensity for life, it may not classic as a human form but under microscope nearly that is wrong with any man is visible, including the cold viruses.  It is not enough reason to affirm that a re-introduction of the Spermatozoa to human body and official status as food not unlike milk from Cow containing the antigen from its ancestors, which are just food when they reach the intestines of most humans. 

 

 

The sperm is not different, when they arrive at the intestines are no more than what they are, food which could be digested – at least by most female. The problem is with the male, the sperm contains element of human beings from male, while the female may recognize it – may still digest the sperm with all its forms as common as a regular milk. The male (my Dogma) do not. The sperm re-introduced as food finds home inside and outside the microfiber of mucous membrane, it is split along with the retentive bacteria or cold causing bacteria; Staphylococcus, Streptococcus, etc, whose forms are no longer useful but acting as a viral DNA, but whose foreign DNA inserted in the spermatozoa of the first male, survives as particles in the second male, and the in this case, we open and conclude, that it is the second male with in as much testicles as the first that re-prepared the food called sperm in spite of its mutant quality into another life, now excreted and now protected by human CD4 first from the first male then entering the second male, permeated in the second male whose sexual activity was the death band of new virus protected through human means in natural circumstance of parallel existence. In the absence of the testis, this would have happened. Put it kindly, the body treats the virus as his own and it goes on to protect it including offering it all kinds of protection, including the special status of the protein-core or reverse transcriptase whose origins should be found in the testis of the male, whereas the “two” tit bits virus or Viral RNA is a foreigner mainly concerned with its profligate activity and in the process hurting the blood reserves of the host yielding the cold as we later find out.  Is like the virus did pass through the female was already late on arriving body. She grabbles with the first protein bi-layer no less similar what happens when the virions binds to the surface of the cells, with CCR5 and CD4. By the time they penetrate the first bi-layer, the main event has already emptied itself into the Cell’s nucleus.     

 

The reason why the virus is a kind of lentivirus or slow virus is that cells and the core-structures are derived from humans, the human cells conditions the foreign RNA as if it is suggesting that it need mature, but once the virions penetrate a human cell, it is let go and in this context repeats a process that took place in its primitive beginning, replicating but conditioned by human cells until it becomes a big problem in the system. 

    

 

 ‘Chymotrypsin is a digestive enzymes that breaks down proteins eaten as food’              

 Ridley in of itself nearly counteracted his theory, with the saying,

This theory may have occupied the minds of many scientist and left many of them wont at connecting a primate and unknown parts of the world – for instance Africa – to events surrounding HIV as it parallels SIV in Siamese. Up to this very moment, many scientist even after William and Worobey has disproved Hooper about Africa, are still looking for the source of HIV. There are none. It is a human virus which if descended through the female Chromosomal inheritance would not have lasted another minute in the XX of a female, but survive only one context. “Luckily, the viral DNA is kept under a sort of house arrest, shut down by a mechanism called methylation. But there is always the risk that a (Herv) will escape, making a virus and infecting our cells from within….This would be an infectious disease, just like any other virus, but it would start within our very own genes and be passed on from parent to child as a set of genes. It would look like an inherited disease but would behave like an infection.” He is not referring to HIV in this particular case, he is making his argument about generational sicknesses and dovetailed on Thomas Hunt and his use of fruit flies (Drosophila) to show why a trait must transferred from age to another in the line of Queen Victoria.      

 

The purpose of showing why the host inhabit protease elements to profligate virus almost like the sperm into the egg, it gives a fair shot at the reasons why the sperm is enveloped by the egg and through the treatment of the air, temperature of the body and natural aging process, these cells divide or immortalize. It is called immortalization. From all earliest symposium on the nature and veracity of HIV virus, there are at least basic synthesis on the operational dynamics of the viruses which is no different from how a virus invades a system cell and how the invasion yields new baby cells. The works of Enders of the profligate baby virus towards a defense mechanism of the body offers several hints of explicating on why the body can effectively defend itself from a familiar attack and how this familiar attack becomes a tool for helping the body improve itself function. A regular cell is protected CD4 receptor and a surrounding CCR5, generally used a docking device for any new proteins or RNA entering the body. 

 

 

Nearly assumption processes of the body is one chain of building block patterning - from the smallest molecular structures; mononucleotides which are the DNA complexes containing the basic ‘blueprints’ so to speak of life – to the proteins themselves and to the cells which contain, nucleus and the protein plasma with Endocystic outlets binding the inside of the cell to other cells through the RNA. To the larger structure of the body in the process that involves reproduction and excretion, through which all the products of the human body; the final organs, the nose, the eyes, the bones, the entire aspect biology and physiology of human body which artificially make human different, and its mammalian tissues that are reduction of individual gene quality, are processes involved in final displacement of the body’s waste products and like the bones mainly Calcium in content, the rest of this body is more or less a final product or waste product, that is unwanted protein structure that began its journey from single process to immortalizing of the cells, in which biological construct and if we are looking to widen our grasp on biology and profligate virus including HIV, must conclusively accepted as similar to the whole of human body, that the human body constitute a cell in the macro and purely working knowledge of the term and the cell like the human body should be seen as an organism.

 

 

The colors of the eyes or the hairs in the nearly all creatures including mammals, are final products confirming the health of the individual gene, which for reasons of human dispersion and reproductive isolation is confined to specific collage of a human and mammalian biological types, whereas these physiology are no more than what they are, final products of unwanted proteins and carbon complexes that the body no less needs. But this organism called human to continue to operate, it must sustain its existence by the promotional activities of the cells in the body as if the regions of the body is profligate by the genes that is positioned in the chromosomes and that therefore the Chromosome could not have occurred as an accident would mean that it is a bi-product of a cell’s summary replacement process, which immortalizes through division, which continues without interferences and which essentially builds like a computer and dies as unwanted final outlines of the physical bare body.

 

 

The hairs of course gradually tingles, snaps and breaks, the nails are cut off when they reach a certain level, the body excretes both the liquid substances that entered into it – either through the primary glands or through the dermis – and all creatures pass the humors substances such as f…as final product…..() repeat….to a point that if human beings continue to keep their nails and their hair as practical examples, they like the tissues stored in some lab would continue to grow indefinitely and out of control. It is the individual – like the cells and the CD4 that regulate this profligate behavior primitive nucleus of the human cells and its achieves this by producing new cells especially cracking the capsids of the presumptive RNA entering the body, for the food in the final sense of its procreative processes as molecules and entangled to each other by RNA remonstration and the binding tie between the position of the nucleotides and the functional proteins’ blue print (DNA) towards a death of the capsids and its resumption after passing a sort of death maze of the cell and the nucleus to be reborn as new baby cells with some information for other cells through the information bearing RNA. 

 

 

It is this opening account and in many ways conceivable that the final products of a system in the body and the production of the organs in the body as bi-product, are mainly interesting in the final product that is XX egg considered the bi-product, contains everything that the body needs to survive, more like proteins, fruits and vegetables, only more prepared pre-baby stages. The other problem is that this protein is less sufficient to protect itself until fertilized and its full capacity realized.

 

It is for this that spermatozoa with its long tails is the seed of life and not the egg. It is understanding this very theory however difficult that gifts you an access into the origins of HIV. It is the father that has the X and Y chromosome, each a copy of supposedly male and female chromosomes, in all possibility, attempts to compare the two testis are posting for male and female failed several German scientist who were also promoting that the men undergoes the same monthly circle as the women. But these were not exactly accurate. The X is no doubt the female, the Y the male, and it is the father has both copies, hence my theory that the mitosis exchange of chromosomes are mainly along the father line, or unless we rename the father; mother. Put it clearly, the woman has only XX protein which is why she conceives, one for herself – the X and the X for that which will be received from the male; either Y or X, meaning we can only have two types of humans, one with X superior, the mother, and then the donor; X or Y > XX or XY. It is in this instant; mode of reproduction, that largely all theories in biology can be explained.

 

The Egg does not contain real life, it is an active stasis alive on the body of the X superior until it is activated by a biological construct similar but compellingly the opposite – the Spermatozoa of the human for human. Like in real life the egg sits or excited in stasis and long comes the spermatozoa and then the bonding. The reproductive processes of woman and her biological structure, may be reduced to bi-product of her body, elevated to significance for its ability to feed the sperm introduced from the male, and the egg pampas this sperm and continues to be pampered by a tube that connects the sperm to the body of the woman, until it assumes its full structures usually after the 21st day. Like the eggs of say of a chicken, the fertilized egg traps a semen from the male and gradually incubates the male sperm as if it were an RNA+ virus attaching itself to a cell until maturation. The egg gradually matures and ends up hatching into a chicken on its final hours. What matters or what happens is that a regular oocyte or egg contains what a sperm from a male chicken needs to survive, that when released from the hen and left to matures according to its duration or as Egyptian discovered and others followed until now, the egg ages with heat application like a natural process, that the chicken gradually absorbs the protein developing from its smallest age till the wings gradually emerge inside the egg and the cells made of calcium final breaks due to age made possible by the last of the protein inside the egg.

 

The calcium is the inhibition in this case which eventually cracks open and the chicken released as bearing the imprints of parents. This is not really a big knowledge, it is how it explains why a new life form could emerge from male to male to male union and be created in the lab which was my personal concern that is the creation of virulent retroviruses. The life form if introduced into a cell stands to be protected by the very human cells that created, allowing the virus to betray the body’s immunity in the long effort as surviving through almost innocent profligate. As stated, many protein building substances cannot survive on their own outside the cell, and such cell and its membrane play almost the similar role of a chicken and egg, and female egg and male sperm, with the cell working like egg and the embryo until the virus mature cleaves off the mother to be used elsewhere.  The Chicken reaches maturation – even denatured – and then breaks the shell, the baby – the human. It re-emphasis the statement that HIV from its structure and its mutant retrovirus behavior did not begin in the blood, its life-form is a cold bacteria; Streptococcus, Staphylococcus, Pneumococcus, etc, or Cold virus

 

 The bacteria was not expected to behave any different, it behaves just like the fertilized egg, but more than anything, we equate this changes due to ‘nature and nurture’ to those of human beings, that the female egg is essentially XX, bears prints of its past (Korentz) but probably not the human lineage in direct meaning of the mitochondria. As unsavory as it seem to sound, the female egg is a cheaper version of the protein that gave meaning to what is considered the lineage of homo-sapiens. In guide light, the fruits of its replication is preserved by the egg and since the female descended from the father, she borrowed at least half of her father in course and struggle for existence. It will not be immediately explicable why there was a reserve from the male side, it explicates that the coupling between the gametes and the mating resulting the diploids are primary digestive process, a self-weighted argument that means to throw light of some cells retain some of its original unity and remain undigested in the course of its reproductive ability.

 

 

We exist because of the women, it looks like we exist because the synthesis involved in the original process of life that a complex can be broken or amended by smaller organism in the body or elsewhere, that in effect, we are descended from less than original human complex, we survive due to the ability of the body to recognize its final product, as if the XX protein for instance are final products of a line that may have started as something else, perhaps like all creature may or may not started as we are. From here, the primary reason for HIV is clearly and visibly stands, that the reasons it manufactures enough of itself may have be due to the protein providing for it, that it grows inside the cell suggest that it had no plans of surviving on its own, that as the cells age and replicate, they replicate this intruder trapped in human enigma. Of course the pursuance of reversing the reverse transcriptase or at least inhibiting its growth, may have landed us on the altar of AZT, but it is a survival kit and not a holy grail, leads us to suspect that inhibiting the activity of the reverse transcriptase which are generally running errand between the trapped intruder and the host, is not a lost cause but not the right attack strategy. The offence lie elsewhere, breaking up the bond that binds the two RNA+, prove of this is that once either of two Retrovirus is separated at any known terminus, either piece of retrovirus will not last.  

 

(2)

 

 Other important association of HIV virus and for important reasons there are three groups we can associate the history and the origins of the virus, for all the intent reasons of digesting the idea from one ends of science to another ‘anti-discipline’. A few definitions on latest breakthroughs in Sciences and biology are usually referred to a few people with years of experience and well expressed theory, and in the case of RNA, ‘Amino Acid’, genetic code, protein, which unconscionable fed interest in Biology, also account for some of the assumption, that for instance the George Beadle and Edwin Tatum’s ‘One gene, one enzyme’ was proven popular to a point that it assumed to be correct – at least in the classical sense of the word. But in the ‘Eight Day of Creation’ the author reminded us of the correction that Max Delbruck made about the assertions by Beadle and Tatum, that it was at least okay to say one gene one prospective mutant, which if grasped could make a line of difference between the Andrew Lwoff seminal theories about the prophage bacteria, that both parties of the bacteria shared a kind of simultaneous DNA paring during copulation, a claim from an acclaimed authority that in spite of B-galactisidase and the breaking down of the complex sugar, resulted a 10 minute interval for the injecting the DNA into the female bacteria – mainly and only be the mal bacteria identified as the F-factor conciliar to a certain William Hayes at the Cold Spring Harbor. What bring these scientist together at Cold Spring is a loosely held theorem of scientific and club relation actioners’ that believe themselves devoted to Science and nothing more. So the destitution of Lwoff and his position is not comprised in the later work on Phages by Jack Monod, and in lime light, the French team leading the chain of discretion from what is left of Pasteur to the holy light of Interferons which became the passions of Luc Montagnier in a total bid of discovering new ways of using the proteins.

 

 We attack some of earlier situational sciences of these men in concert with Salvatore Luria whose work on bacteria phages inundated the career of the famous Max Delbruck called by many as primus inter alia in phage studies and eventually at Cold Springs. Delbruck defined several Dogma in biology and remained among the crème in molecular biology and sciences alongside Luria, Sanger, Pauline, and Perutz. But in total acceptance that his critic of Hershey and Chase experiment does reach the land of reasoning, that these men equally gave meaning to the use of Phages in experimental biology and the use of prophages which in some cases deposit a part of genetic material to the female bacteria. There cases when the bacteria or micro-organism are not able to synthesize some of inherited genetic proteins, they are parceled together into new forms of information pathway that retains a part of the mutagenic particle which is retained in the new bacteria. Our bodies are not that different, operates like the single cells and carry cells from one generation to another but only if the female partner do not have an entirely different set of replacement proteins.

  

 Hershey and Chase’s experiment to illustrate the permeation of some of the assumptions in the challenges of DNA as the property that alighted the characteristics in human body and not the proteins as earlier suspected. But the results were poor as according to Delbruck and the experiment was not exactly elegant, but it penance which survived the critical era of gene transfer, into the new realities of DNA – both in the tradition of Chargaff and Pauling, and in the traditions of viruses that make all differences for the prophase level. Separating the protein from the DNA in Warring Blender has left a lot to be desired concerning the DNA, but ultimately, it was the work of Watson and Crick that brokered the difference between RNA and DNA and science has not been the same ever since. In later years, there will Jack Monod and the struggle to elaborate on the bacteria phages leading to his entering into Andrew Lwoff’s office and in in spite of the problems associated with repressor genes and RNA, which in limelight of the Leo Sziland can be made to conform to the statement of Beadle and Tatum that some activity of the repressor genes and the some activity of the activation genes do and probably determine genetic expression. The whole world of reverse transcriptase and the world of social as well the eventually breakthrough with excision enzymes, of HOX and SOX enzymes, and in particular the role of a transition gene responsible for turning of the genes and helping a chromosomal expression was settled in the light of SRY which for humans proved the genes  that is responsible for deciding Sex gametes, particular in respect to Hayes but largely and by extension, the work of Andrew Lwoff despite the earlier flows.     

 

 Frederick Griffith in 1920 “transforming principle” also used by Oswald Avery much later, discovered in ‘Streptococcus Pneumonia” from the bacteria that causes – pneumonia derived from his injecting a mice with a (smooth bacteria) (S-bacteria) caused lethal infection…but injecting the mice with rough bacteria did not cause infection. When he killed the S-bacteria by boiling and injecting into the mice. It didn’t kill mice. But when he mixed the smooth bacteria with rough bacteria – it proved lethal to the mice……     

 

When Oswald Avery performed the experiment we wonder why he failed to inject – the new (S) smooth bacteria into the mice….to see if it could not immune response…..Oswald Avery, Colin Macleod and Maclyn McCarty – that it was Purified DNA that transformed the rough bacteria into something else. Albert Hershey used viruses to convince Biologist that DNA was the ‘genetic material’ and Watson and Crick eventually demonstrated how it worked. Delbruck however made it clear that the biological arrangement of Hershey and Chase did not present a good result, as opposed to the experiments performed by Oswald Avery who was already expansive in many ways than one, was careful to control his loathing in science but somehow did not generate enough faith in many followers. James Watson and Francis Crick using X-ray diffraction As, Cs, Gs, and Ts, Francis Crick called the Great Sage of molecular biology produced the theme of Central Dogma….(Replicate) DNA – (translate) RNA – (translate) Protein Central Dogma – that all cells use DNA for storing – passed from generation to generation in the form of double stranded DNA, and it is in human a ‘three billion nucleoside long’ could require longer transformation process.

 

In dealing on DNA, we may profit from names such as Erwin Schrodinger who credited with connecting Amino Acid to hereditary, though he provided no documentation or experiment. But in written text, there is a definition of RNA and DNA by Ed Regis that merits a citation, in his (2008) ‘What is Life’. There is some comfort in his definitions that ‘RNA was similar to DNA in that it was a large, long macromolecule composed of a sugar phosphate backbone and four bases, or repeating subunits. But RNA differed from DNA in several respects. For one thing, whereas DNA was a double stranded molecule that is replicated, RNA was a single a single stranded molecule that did not. For another while they shared three bases (adenosine, guanine, and cytosine), they differed in one’s DNA’s thymine was replaced in RNA by Uracil. Third, whereas DNA was DNA, there were several different types of RNA; messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA), among others. Finally, there was lots more RNA in cells than there was DNA; in fact, RNA was five to ten times more abundant than DNA in average cell.” It the cells and the cell wall that continues to male and female gametes, and why the cell in terms of the production and control of genes or in terms HIV may prove to have followed the path of the digestive tract as opposed to the blood repository of the Virions which is the madness of today’s sciences.

 

There is hardly a better definition of the RNA and DNA in terms of all the studies in terms of molecular biology. It makes a complete sense in the names of what we intend to explicate concerning the origins of HIV, that a comparison between the bacteria that feeds on human hosts, its mode translation and fertilization, which from the fungal yeast, border of the balance better the factors that control other yeasts in the body or in a plant and the possibility of these profligate towards fermentation or transfection leading to transformation of one substance to another. In the course of the general theory, we not need to be party to some of the assumptions about the depression caused by the presence or absence of peculiar bacteria or Viral DNA, that virulence of any virus or bacteria, is perhaps a general formative from the depression in some of the limiting growth factors, established for Diphtheria is protonsil and for staphylococcus it is was penicillin. Let pretend that the whole of RNA that discovered in the body are usually a product of some transaction, meaning that RNA with positive and negative charges are said to represent a period and a time in the life of bacteria, or a phase, that from all experiments preceding Watson and Crick, it was probed that DNA from the bacteria like those of E.Coli, means that a negative gram of protein and positive gram of bacteria program explicates on its past.

 

Looking at the account of Shane Crotty (2001) on the life of David Baltimore ‘Ahead of the Curve’, whose ground breaking discoveries on reverse transcriptase, places him on the same level as those of Crick and Watson, perhaps of a slightly lower pedestal but in HIV school and the such for cancer cure, he is first class scientist. Worked with Polio Virus stored in the filtered Calf blood and was familiar with Oncogenes which are Lentivirus, but his work on Cancer convert him to the discoveries of the expression cancers of , v-abl, v-src, c-abl, myc, c-myc, the bcr-abl hybrid, ha ras….. In the course of the discussion, Crotty asked “what is the Jekyll and Hyde connection between the normal function of human oncogenes and their cancer-causing mutants? Why do viruses like Abelson virus have cancer-causing oncogenes? That it looks that the NF-kb ‘a master control gene in immune responses and the rag recombinase genes (which generates a large percentage of antibody diversity)’ and draws on the single gene single enzyme paraphrase….

 

Enzymes helps to breakdown food “….Chymotrypsin is a digestive enzymes that breaks down proteins eaten as food. The proteins enzyme alcohol dehydrogenases breaks down alcohol in the liver. Beta-galactosidase is a protein enzyme that cuts lactose, a sugar, into two pieces; glucose and galactase” (Crotty, 2001). For him in this studies that leads us to transform some of the principles of biosynthesis of mutant or defective Neurospora such as Amino Acid, Arginine and tryptophan, where he made mention of Beadle and Tatum that connected a single gene to an enzyme…..Arg-3 converts molecule citrulline into the Amino acid Arginine -……Joshua Lederberg and use of E. Coli in demonstrating the transfer of genes between bacteria…Deficiency could point to the shocking gaps in the genetic content and through effective research E Coli. Coded one genetic content….one the male E.Coli can pass genes to the other the female…E.Coli. E Coli normally grows in the human colon at optimal 37 degrees which became a staple for labs…..DNA made up of monomers which link together to form a chain. There are four different types of monomers of protein and 20 different types of minerals. Monomers of DNA are Nucleotides which exist according to their bases (a) Adenine (b) Thymine (c) Cytosine (D) Guanine……

William Cookson identified a gene that is responsible for immune response to Asthma….

 

 

For how could it missed that some bacteria, such as Streptococcus is considered gram positive bacteria, to modern scientists it is an RNA+, it role is therefore described that to the extent of Lwoff that B or bursa cells in human beings seem to congeal under the flask of RNA- , that the attack on the b-galactisidase leading to culling up of some the bacteria, where the lactose as a premier element is isolated through the activity of bacteria, unless as someone pointed off, there was mercury involved. For that the seminal theory between the RNA+ usually an antibody entering the cells, may require the permission of a CD4, which is though circulating the surface of a cell, is by all means a bursar cell. The killer CD8 cells are primarily late comers to the encounter between the CD4s and the new arriving virus. For science, we point out that lac I gene, or a strain of bacteria with lactose inheritance from B-galacticidase, propels the argument about the originality of a strain of bacteria, explicates its past through the sex gametes that determined by the F-Factor, measures up to the conjugation of the possessing bacteria, transform some of the assumptions in the chemical complex by injecting into the plasmid, its DNA, while totally losing the old structure of the bacteria. 

 

 It is the role of the B-cells that make this possible, that compels a conjugation of an F-factors, that measures its existence, that replicates its existence as a DNA, and among other things – the ability of the bacteria or the female component to accommodate the male factor, suggest that the growth and rebirth of the bacteria is achieved exactly in the female and not the male, that the provisions for future proteins that are capable of being a structure or crystal is for all intent purposes, the reasons why thymine play such significant role in repetition of a DNA sequence of four lode protein of hematologic blood borne oxygen depended molecules, whose base line sequence and the sugar phosphate is the complex ‘Guanine-Adenine-Cytosine’, with the highest three level hydrogen being evident in the Guanine+Cytosine (GC) bonding, for if the comparative is made between GC bonding of 3 hydrogen bond to Adenine to thymine, (AT), there is a fractured covalent bond to the tune of Thymine, that it looks from all four sugar phosphates that Thymine is to be looked at the most prone to adjust, like the plausibility of the Three dimensional Blood Hemoglobin, depression of the complex when in contact with low oxygen region of the body unleashing a forged but reactive other complexes that have a temporary formations, which crumbles as the Hemoglobin complex travel into the rich oxygen territory. The point of the role of oxygen and the removal of oxygen through hieroglyphic iron bonding, is a by default the role of thymine, who main event is attempting to adjust to the demands of the body give first the presence of oxygen is replaced along the ionic surface, for with this, it increases the presence of water, H20 or increases the presence of Hydrogen towards a better bonding for instance GC bonding.

 

 The opening is not to show that the deficiency of Red Blood Cells in body of sickle cells patient, very characteristic of HIV patients, including the unfortunate loss of blood and anemia, pre-disposed by several agents including Pneumocystis Carinii Pneumonia, leading to poor formation of the Red blood cells due in part to prolonged exposure to illicit drugs, cortisone repressing immunogenic to thymine, due perhaps to other activities in the body, leads ultimately to the changes that are visible from low production of CD4 or T-4 that are Oxygen and Red blood dependent, hence thymus depended cells, to low frequency of the blood itself in guise of modern sciences that thymine, was a weaker covalent bond of 2 hydrogen pair, and therefore susceptible to bacteria slitting b-galatactisidase, and in this case we identify Streptococcus as the splitting agent.  The impact of Streptococcus on thymus is not well studied, but we can rest on this premise, since the presence of the ancient n-bacteria has been around for as long as man, to a point that the oral candidiasis which was peculiar to the male Gay couples at the beginning of the consciousness on the subject is not without a relapse to rheumatic fever itself a bi-product of Streptococcus induced lytic Candidiasis, a once dormant virus now profligate on account of depression in system, on account of  

 

 

Following his footsteps of Gallo and perhaps an effective scientist on his own right in Jaap Goudsmit, who like Frederick Sanger, developed major interest in the biology in ways that were not exactly placed on perspective, particularly in HIV studies where he is considered one of the foremost authority on HIV, Beatrice Hahn, Myron Scholes, Michael Gothlieb, Michael Popovic, Jay Levy being among the notable names, of course Myron Essex of Harvard School of Medicine and Myron Scholes of North Carolina could be added, but these are primary list associated with specific invective and are schools on their own – including David Baltimore. In Guadsmit (1997) we try our faith on the virus in the context of the life-strain which has been in the possession of Gallo, for all intent of academic reasons, there is a mention that a familiar kind of strain used in navigating the earliest promises of the viruses, and his book, ‘Nature of AIDSD’ is a 1976 “isolate of (strain HZ321) is our earliest actual of HIV, since no virus has yet been recovered from the Norway sailor” and this isolate was comparable to the Zairian HIV – IA isolate and seem to be comparable to HTLV – I and Human T-cell lymphoma and Leukemia viruses, and “Also known as lymphotropic viruses, these retroviruses are not lentiviruses but oncoviruses. They seldom cause disease or meet HIV in the same cell but are prospective HIV partners for production of recombinants. In monkeys they are STLV – I and II.”

 

 But according to Deusberg (2003), in 1985; Gallo changed the name in 1985….for the human T-cell leukemia virus – substituted it for human T-cell lymphotropic virus meaning infecting T-cells, that “A sample of the leukemic T-cells, originally named HUT78, was sent to his lab for isolating leukemia virus.” But Deusberg did not specify the strain of virus that Gallo took, whether it was the one from Zaire or some district in Africa. That they dovetail the leukemia causing cancer virus in Cancer, means to add that their prognosis of the Feline oncogenic virus, is prove that the Elly Lilly and Rockefeller  Institute were familiar with the ‘…cases of ‘Feline AIDS” (FAIDS), which are Deusberg mention was isolated as “simian immunodeficiency virus” and blamed it for “AIDS” in monkeys (SAIDS), all of which are product of the 40’s in U.S and in France, and then 50’s were the curtain gradually fell for the rest of the biological scientist. That in limelight of those who discovered the oncogenic viruses or isolated it from the strain of a cancer causing virus, it was achieved in 1951 at Rockefeller Institute from possibly a strain of the Congo virus. It means that the dives on Gallo’s HIV buffs, is probably not new, may started as a trial in the context of  the theories about Viruses and primitive parts of Africa.

 

 

If we are to break it down, it almost seem to point out the that strain of Gallo’s virus that was available for processing and was available for early consumptive laboratory work was from a strain of the virus from Zaire, that it may have a common physiology with the strain of those of the Norwegian sailor, even in his estimate the man was no longer available.  It will seem also that the comparison between the Lentivirus that Montagnier is associated with is not unknown to Gallo, promotes only two possibly arguments that Robert Gallo were looking at the comparative physiology of the primates and the humans, their gaps in defense mechanism and whole comparative physiognomy, that he believes in lieu of Rockefeller Institute and their historical breakthroughs, that a similar virus if discovered in the primates can lend a pair of eyes to those of humans. The second reasons is that he and his group may have believed upfront that the virus essentially came from Africa. It is only reasonably reassuring that Interleukin-2 associated thymus which Montagnier emphasized has its reasons, based perhaps of Claude Jasmine Chermann.

 

 When we look at the structure of the protein from sources totally available to us, the use and eventually the abuse of Gallo’s strain resulting in its isolation of the human version of the Zairian Strain, is said to be oncogenic virus, means that it is cancer causing, will also point to the fact that over the last returning decade of the search for HIV and its cure was sentenced to a goose chase, point must be made that the strain however oncogenic could not connected to human cancer, though the virus when triggered delivers according to its purpose. Therefore a connection between the cancer virus and human immunodeficiency virus were test that led to wrong conclusions, for if HIV in of itself could infect monkeys, a kind zoonotic trans-infection would be possible among the humans. Looking at the conflict in the early years between Gallo and Montagnier, it is becomes gradually clear that Montagnier or the house on which Montagnier is based would have collapsed, were it not for the fact that he did specifically mention that he used the Interleukin-2 protein induced virus to isolate the HIV virus, suggesting that he was right that the virus called HIV or initially a LAV virus was different from Gallo’s Virus.

 

For the similarity and differences between Gallo and Montagnier, it will be common sense to show that cancer is the bottom line in whole argument, while the Gallo cancer causing virus is different from Montagnier is perhaps due to their specific origins. Although there are other viruses that trigger the creation of mutants, the rate at which we notice the differences between the two scientists is what their viruses do inside the body. HIV can be called a kind of cancer, perhaps blood cancer given the long held observations of people with the virus and may have been the motivations behind the use of cancer agents with direct reference to the blood. But it is the blood that matters, what happens to the Red Blood cells over time which ends up affecting white blood cells or CD4 counts over time. A dip in the CD4 counts eventually comprises the body’s defense systems. We are now certain that AIDS patients die from Opportunistic Infection (OI) and not from HIV itself. Looking at the history of HIV from these schools will arm with some basic understanding on why emphasis on thymine very central towards the survival of the patient, and why most efforts in correcting the reverse transcriptase did not perhaps lead to any new grounds. 

 

 Flossie Wang-Staal researched with great success of the structure of HIV, and it was the knowledge of the transcription factors acting on the HIV, especially in the introns and enhancers, the terminations point of the Amino sequencing that provided the base-board for developing AZT, which implies the phosphate roles of thymine and was set then without knowing against a alu genes. The marking in terms of the transcription factor largely because HIV is replicated at the right of the LTR, but seem by its transcriptase to have perhaps started its origins at the left of LTR. That it is no use and cannot really affect humans as such the placement of the virus at whatever angle and its conjugation to the nearest human cell which replicates at the right of LTR as with Amino Acid, prove to be well meaning for a healthy life of a cell, but this key location could also transduce a mutation leading to cancerous edifies or creation of mutants. For all intended reasons we presuppose the methyl alu genes is a jumping genes that is not insubordinate to mutations, and should be classified as mutagenic. Alu genes are relatively twisted does not mean they are retrovirus or retrograde, but there are reasons why these twist, they reveal a different version of the genetic DNA especially among Africa Blacks. It is suggested that this is part of their evolutionary past is prove to the causal link between the past Great Apes and the present but these are alu are not formed in the Great Apes and not prions or dangerous 

 

The man who whose theory on defective protein and prions, whose work is Stanley Prusiner. Whether the constipation of the alu genes or the jumping genes that confirms Stanley Prusiner (U.S) long lived Noble Prize on Prions as infectious proteins, we are clear that infectious proteins are mutagenic and does not inspire a transformation from one form to another, a saturated argument anyone can make saving for the vast implications in phage studies. For sure if in more recent times, that Arjit Varik and Elaine Muchmore in trying to adapt a new drug to enzymes working to oppress the profligate of HIV did not award much help, there is then something wrong in the process, a misleading grasps of the fundamentals of molecular biology or in recent times, RNA sciences. “By 1998 Varki knew why we were peculiar; a 92-letter sequence was missing from a gene called CMAH on Chromosome 6 in human beings, a gene that codes for the enzyme that makes GC.”  ‘Right in the middle of the sequence was an Alu genes = ‘Jumping genes.  “So sometime after the divergence of the human and chimp lineage, this Alu had done what it does best, which is to jump into the CMAH gene, swap places with the older Alu, and accidently remove the 92-letter chunk of the gene while it was about it”

Throwing stitches….using his exert quotations, the “Hox genes are the recipes for proteins called “transcription factors”, which means that their job is to “switch on” other genes. A transcription factor works by attaching itself to a region of DNA called a ‘promoter’, where IGF2R gene on Chromosome 6 ‘Premature damage to the brain or late development…

 

 AZT as described by many experts is cell mediated immune response where AZT is incorporated into the host cells, DNA, and as Irwin Sherman suggested it is shown to be introduced in some numbers in the DNA which is set to clarify what Peter Deusberg mentioned that it actually tampers with your human DNA, whereas the Factor VIII mentioned by Deusberg is not exactly anomalous may prove to be relevant to Hemophiliacs…..On AZT a ground breaking theory, we have noticed the work of other experts such as M. D Grmek (1990; translated by Russell Maulitz, Jacalyn Duffin), that points out the evolution of the disease in six hierarchical stages and according to the maturation of its protein, which for the author reflected “the chorological and biological status of infection…” and it is A, T, G, and C, that make up DNA…..3-azido-3’-deoxythymidine – or AZT…., the Antigen-presenting cells and whose Human leukocytes, Storm trooper T cells antigen (HLA), Viral antigen, T-cell receptor (TCR) and in one major

 

 

Dani Bolognesi, the whole structure of HIV protein fell, with one particular emphasis of the gp120 envelope glycoprotein. This gp 120 proved a deciding mark in the renewed assault on HIV sometime in 80’s and it revealed considerable presence of what he called ‘main proteins’ (P24/25 inside of the protein box, and gp120 and gp41-43 outside) whereas some of the proteins are well to share comparative similarity with sooty mangab1ey (cercocebus atys) which carried a strain of the virus (STLV – IIIsmm) inside.  In relation to these strain of viruses, there are lengthy….Grmek as one the foundation members of the war against HIV mentioned understanding the cleavage enzyme that was delayed in the orchestration of the CD4, and the primary.

 

 

‘To this end, biological modifiers of the T-lymphocytes, such as interleukin-2(IL-2), hormones derived from the thymus gland, or thymomimetic drugs (DTC, commercial name imnthiol), were tried, as well as transfusion of HLA-matched lymphocytes or even bone marrow transplantation.”

 

“The first of these products autoimoniotungstate or HPA – 23 (so named because it was the twenty – third heteropolyanion synthesized by chemist Gilbert Herve and Andre’ Teze), was known ever since 1974 work of Claude Jasmine Chermann as an inhibitor of reverse transcriptase in the retrovirus responsible for murine leukemia and sarcoma. Chermann studied its action on the AIDS virus. HPA -23 inhibited the activity of LAV reverse transcriptase in vitro.” And for this breakthrough studying the reverse transcriptase is greatly advanced, has dominated a lot of studies in this respect excluding gene therapy in very recent terms.  

 

 Michael Bishop and Harold Varmus discovered that “virus-encoded oncogenes originate in eukaryotic cells.” But it will be the Gallo team that will make the better of this theory, and if in the decision which lend meaning to how some of the theories of oncogenes that dominated the early and later stages of Baltimore is placed on the same context as Gallo as he presented some of his assumptions.

 

That “The HIV dissidents could see two fundamental problems; HIV was a retrovirus, meaning it should not kill the cells it infected, and the virus could barely be detected even in late-stage AIDS patients”, Deusberg (2003) which threw its own light in the context of well understood realities of the Virus and why it remains part of the human body in spite of the drugs released to deal with it…..Although Deusberg and company need to place some faith in the assumptions raised by the two leading schools of Gallo and Montagnier, the later holds more promise but Gallo may have struck an ideal comparative between the operational dynamics of a leukemia virus – perhaps in the discipleship of Stanley …..and his prions which are destructive proteins which also have origins somewhere else, and still for reasons not exactly clear is short of the right stuff in fishing the left and right of HIV when the CCR5 is knocked out in experimental relocations of the…..

 

 

In the event that some worrying castigations on the number of failed vaccines – at least well-meaning 20 vaccines - can be left to the primitive carousal of a CD4 protein inhibitor by name nef so named by the company that identified the proteins which HIV DNA based do not produce, it may not escape our mind that the intrepid connection between the SV…..In one Deusberg’s exertion’s “AIDS is not a disease. Instead, the AIDS Syndrome is a steadily growing collection of (currently) about thirty “previously known” (old) diseases. Surprisingly, in view of their notoriety for AIDS definition.  It is true, however, that the incidence of AIDS diseases has increased dramatically in the 1980’s as intravenous drug use has increased and as both the consumption of recreational drugs used as sexual stimulants and the use of AZT as antiviral drug have increased in male homosexuals….”, may true to a large possible extent, that the problem of HIV viruses, as they apply to Deusberg theories, is not necessarily the lipid bi-layer of its outer shell which duck the human cells containing CCR5 receptor, which also promotes the second attachment between the Virus and the ducking CCR5 from the HIV virus.

 

Leads to some conclusion that emphasis on the virus on the context of its ducking technique, is only correct by some extent alone. That the problem of the Virus is not with outer most cells, it is with core-protein of two split Streptococcus placed some arrest by some CD4 who origin can be buttressed by the core-protein of HIV protein structure, showing that it is operation at a DNA viral level, would not naturally mature into adult Streptococcus, that is splits ends RNA+ virus whose primary existence is the B> bursar cells that is similar in composition Amino Acid from more older cell wall controlled and depended interactive from and mononucleosis as presorted in Cytoplasm during meiosis, that it farcically relocated in the human cells which re-dominates the virus, controls but does not effective destroy it. It looks that the Streptococcus is one the few capable viruses inside a human cell that profligate by relative contrast between the Amino Cells,  

 

 

 

 

The marginal theory of knocking out the CCR5 viruses as postulated by Francis Collins, Nathalia Holts, and to some degree new edge industries, that there is nowhere that we can impose on the variety of a particular strain of protein, that then as well now seem to temporarily knock the virus’s ability to penetrate the cells. This was the point raised by Nathalia Holt (2014) that by knocking out the CCR5 genes that circulate along the walls of the cells, it may reduce the human vulnerability to the Virus and hence led to material occupation of therapy with engines of superficially designed immunologic viruses towards reducing and actually knocking out a gene that “HIV needs for entering cells. We could knock out this gene in stem cells and then infuse them in a patient. All the immune cells that matured from the progenitor cells could then be resistant to HIV. The hope was that this therapy would create a functional cure the likes of which had been seen in only one man; the Berlin Patient.” 

 

Holt mentioned that HIV operates like cancer move from one cell to the rest of the cells….citing Broder.... “Principles, drawn from the world of cancer had significant implications for the development of antiretroviral agents, starting with AZT.”   “In 1993, the Berlin AIDS conference crushed the hopes of these desperate for a new drug to treat HIV. The drug they were waiting for was still two years away from being approved by the FDA for use. That drug, Saquinavir, was designed from the crystal structure of HIV’s protease enzyme. While, in 1989, everyone though Merck-was the first to deduce the Crystal structure of the viral enzyme, molecular virologist at Roche know that the structure was actually quite different. They development the drug R031-8959, or Saquinavir, based on their modeling of the target.”   She continues that interference of RNA interference “How HIV invades a cell. The virus first makes contact within a T-Cell, releasing its enzymes and RNA inside. The reverse transcriptase enzyme translates the viral RNA into DNA. The virus then makes its way to the nucleus where the integrase enzyme hide, the viral DNA within our human DNA. The viral DNA is transcribed back into RNA by the cell. Our cell then makes viral proteins as directed by HIV.” 

 

“The protease enzyme assembles these proteins into a virus. As the virus leaves the cell it picks up proteins from our cells membrane, giving it the key to unlock more T cells.”  That “HIV is able to break into T cells because of the proteins the cell holds on its surface. HIV needs two proteins to sneak into the cell. The first is CD4. T cells with the protein CD4 are the commanders of the immune system.” 

 

 

 Francis Collins mentions in his book a presence and the purpose of a collection of gene called CFTR genes, which is his words normally codes for a protein that transports salt and water across cell membranes in various organs.  ‘But if both copies of the gene are misspelled with mutations such as f508 (a deletion of CTT) OR G551D (a substitution of A for G), the result is cystic fibrosis’ “The realization that most cases of cancer of the cervix in women are attributed to exposure to a particular virus – human papillomavirus (HPV) - and that this virus is nearly always acquired by sexual contact…” There are no ‘preventions and interventions for hepatitis C and liver cancer, and Epstein – Barr Virus and cancer of the head and neck, especially in Asia” Molecular discovery to magic bullet …“Judy Orem was diagnosed with Chronic myeloid leukemia (CML) in 1995, when a blood cell count was 66, 000, about 10 times normal” Myeloid Leukemia….

p.148 ….The founder effect of those Africans who came there first. (2) The Genetic drift random slow movement of all people

 

p.150. “Specifically, the gene SLC24A5 turns out to be critical for the production of melanin, the predominant dark pigment of the skin and hair. In Africans, as in most other vertebrates, that gene is fully functional. But virtually 100 percent of Europeans have a mutation in SLC24A5 that greatly impairs the function of the protein. Thus it is fair to say that all white-skinned Europeans like me are mutants! Interestingly, Asians have the fully functional version of SLC24A5, but have acquired mutations in other genes that result in lighter skin, while retaining black hair”

 

‘The evidence suggests that in our common African ancestors, the ability to digest milk was turned off at about the age two.” The lactose he mentioned in the body of African Child stop working and seem for the child to diarrhea, bloating, But this is perhaps due to the active DNA of the Child that place and with the adult of the Africa…Sickle Cells traits was looked at with the view or ability to protect against ‘Malaria’, +but this sickle cell may suggest a relationship to chimpanzees defense…..Conditional biological defense usually lead to cystic fibrosis, sickle cell anemia (Africans) Tay-Sachs diseases (Ashkenazi Jews). Requires HAART ‘Highly Active Anti-Retroviral Therapy’. A man cured of stem cells for described HIV/AIDS as ‘diabolically clever AIDS VIRUS (HIV); HIV is encoded with the RNA….that is “diabolically clever AIDS virus (HIV) docks to the normal immune cells surface proteins CD4 and CCR5, and then gains access to the cell. It goes on to make copies of itself, destroying the cell in the process” 

 

 

 

 

 

It looks from all intact of medical practice that this will temporary forbid the penetration of HIV into the cells, but it create a long term deficiency of proteins necessary for a healthy cells, the cure if effected could be done at early stages, for all that it represents, the theme of using the proteins that HIV does not produce to combat its methylation on the short as explicated with the APOBEC3 families of lipoprotein, indicate to a large probably extent that the APOBEC3, are used to temporary relieve the methylation of cells, help to promote new cell production, may be good to a large possible extent on the premise that it may help to transform the cells towards altering the delivering rate of Amino Acid and repair protein, that it penetration of the liquid bi-layer of the ions and the solute, compel additional penetration of Amino Acid based protein

 

 In the paper titled ‘Innate immune system can kill HIV when a viral gene is deactivated’ of the North Carolina School of Medicine briefly stated that, “All family of human proteins APOBEC3 effectively restrict the growth of HIV and other viruses, but this action is fully counteracted by the viral infectivity factor gene (vif) in HIV.”, and going by the paper ‘most commonly transmitted strains of HIV are completely neutralized by APOEBEC3 proteins when vif is removed from the virus.”, and the paper concludes that ‘without the vif gene, HIV can be completely destroyed by the body’s immune system.” While there are no first hand showing that this assertion is correct, the theory is fundamentally flawed on the context several reasons, one is that the human body cannot destroy HIV, and the reasons as I pointed is that the Virus is trapped in its primitive core by a human protein, essentially trapped in a b-cell or similar CD4, which provides the reasons why it mast a response to CD4 and CD8 in the human beings. In guide light, we can incorporate some of Jack Monod’s conclusions that repressor enzymes can be determined by ‘end product’, a reassertion of the well-known familiar construct that for instance the presence of some bacteria can inhibit and perhaps control the growth of certain bacteria in the body, such as Streptomycin, Tonsil, Penicillin, etc,. And for that single reason nearly all the drugs which are used against HIV is genuinely dangerous, to the point that these drugs in of itself prove dangerous to human body.

 

In Symmorphism – the role of lipoprotein is better explains, we can look at the premier Kleber’s rule, that “The metabolic fire requires both fuels and oxygen, so ultimately we must relate it to cellular biochemistry, to ecological feeding strategies, and to the logistics of respiration and circulation.” In studying the use of enzyme for studying allometry Kleber’s rule is confirmed by the statement that “…rate of clearance from the blood of the substance para-amino hippurate (PAH) by the kidney can be used as a measure of plasma flow through the kidney.” It is an interesting notation that has a long chain inducible biological history.  The Book Symmorphism (Ewald R. Weibel) continues that, “All eukaryotic cells are built on a basic plan that establishes the order in which different cell functions are performed under suitable conditions. The main structure elements are lipoprotein membranes that separate different compartments. A plasma membrane bounds the cell at its surface; it comprises a large array of proteins that are inserted in the lipid bilayer and form different functional entities, such as channels for ion and solute exchange, proteins for anchoring other cell structures or other cells, and receptors for signaling molecules or antibodies. The lipid bilayer makes this membrane practically impermeable to ions or aqueous solutes, establishing a strong electrolytes gradient between the inside of the cell and the interstitial fluid by the activity of specific ion pumps, such that the inside is Potassium-rich where-as the outside is abundant in sodium. This gradient establishes on electrical potential across the membrane; in nerve and muscles cells transient changes in this potential are used to transmit signals that trigger cell activities.” Unless this protein can not only penetrate this lipid bi-layer but distort the cell productive instincts – which is possible – the reverse transcriptase or the protein core of HIV protein, is hardly affected.

 

Of course it may seem likely that using a line of protein to renew the body’s immune defenses is useful, saving that APOE proteins are low protein ridden to toxicity, unless it could penetrate the protein-core of the HIV largely over a period of time, it may not offer any genuine interference with HIV unless these lipoproteins can penetrate protein structure of HIV, and in the process of digestion, or attempt at digesting the RNA based particle ends up breaking the two Viral RNA from bacteria comfortable with human beings. Put it kindly, the reason why drugs are ineffective against HIV is that its virions contain human DNA, its defense system is made up of human proteins, its compositions is entirely human saving that the Viral RNA is from a DNA that is not human. As such it replicates towards its own good – at least on its primitive core, it profligate on its origin and when it continues to expand, it becomes a problem for the rest of the body.  At the absence of a growth controlling factor, most micro-organism will continue to profligate, and as they attack food injected by the body, the build DNA from similar substances found in the body, for instance, at the absence of thymine is food broken into absorbable substance, these micro-organism use a thymine base substance, for instance Bromouracil-5, largely occupying the 5th position of the thymine base, since the connection between the Sugar complexes and Lactose are complexes that some bacteria cannot break down to manufacture B-galactosidase, which as Melvin Cohn demonstrated, can be carried from generation to another if ingested and retained by human cell, that b-galactosidase couldn’t for thus reason prove to be a protein builder on its, it was always to be located in the cell, therefore, the primitive activity of some virions or retrovirus is that they exist on their own between their own viral RNA and the RNA located within the cell wall of the host, all of which couldn’t have begun accept through a reproductive state.

 

Most of the bromouracil-5 with thymine are not real thymine, becomes mutant over a period of time, like the a construction alloy in atrophying body, or the displacing of methionine or valines in the blood of a sickle celled, for if the three dimensional protein is not well formed, the red-blood cells largely on account of thymine may build similar protein with crystallography different from the building three dimensional block of the protein but are likely collapse when in the region of high oxygen. So long as mutants are no considered to have a life of their own before immortalizing, there is one reason why they become immortalized,  

 

 Presenting the argument on HIV in such a way that it accommodates the various schools of Luc Montaigne and Robert Gallo, two of whom are among the foremost experts on the subject may defeat the more troubled waters of Peter Deusberg and his colleagues that attempted in the early to mid-90’s to dissuade existing disciplines on the credibility of HIV as a causality for AIDS.  There are several effective arguments for both sides, but it terms of the subject, we may be careful to adapt to Luc Montagnier largely for the acceptance as the deciding influence of separating and identifying the virus, but also for fostering some of the earliest breakthroughs on HIV, working at some point along with Jonas Salk, Charles Mereuix, Jean Paul Levy, Paul Luciw, Simon Wain, Mika Popovic  who was himself the assistant and comrade to Gallo, and the some of the names that has made breakthrough on the subject of HIV, which in his words has become a discipline of his own... book, Virus 1999 fresh from the convictions on isolating the Virus in 1983 and according to him “The study of AIDS has become almost a discipline unto itself. Two important new paths loomed before us; to understand first of all how the virus, by infecting only a few lymphocytes, was able to destroy the whole immune system; and second, to understand better the role of co-factors, mycoplasmas in particular, in the diseases’ development.” The layout  was short of proving a an artificial frame work for understanding the preoccupations of the current medical scientist and ensures us that mycoplasmas play a deciding role in attempting to further our understanding of the Virus and perhaps develop a means to end it. It seems that the ‘heroic age’ as put it is over, that we are at the phase when there is only day to day information of the latest pitfalls about HIV.